Roberto Giovannoni - Researcher

Roberto Giovannoni - Dimet 150x150a Department and institution: School of Medicine and Surgery, University of Milano Bicocca
tel. +39 02 64488231
Curriculum Vitae
institutional profile page: UNIMIB
see also: PubMed, BOA, Loop, ORCID, Linkedin, Twitter

Research interests

    Dr. Giovannoni has focused his research activity mainly on the production and characterization of experimental in vivo models for human diseases. The investigation of pathogenesis of human diseases in experimental models has been carried out in the following research projects:
    - Study of molecular and diagnostic markers in cancer biology (Romano et al, Oncotarget, 2016; Giovannoni et al, Hepatology, 2016; Grassilli et al, Oncogene, 2016; Agostini et al, Cancer Biol Ther, 2015; Grassilli et al, PLoS ONE, 2014; Grassilli et al, Clin Cancer Res, 2013)
    - Study of the role of nitric oxide and heme oxygenase-1 in the prevention of intimal hyperplasia development in an in vivo model and in vitro on vascular smooth muscle cells (Cerrito et al, Biol Pharm Bull, 2011; Scagliarini et al, Basic Clin Pharm Toxicol, 2008)
    - Study of the effects of statins on the systemic inflammation induced by hypercholesterolemic diet in a pre-clinical swine model of vascular injury (Busnelli et al, PLoS ONE, 2013; Busnelli et al, Atherosclerosis, 2009)
    - Production of hCD55-transgenic pigs for xenotransplantation studies (Lavitrano et al, Methods Mol Biol; 2013; Bacci et al, Theriogenology, 2009; Smolenski et al, Cardiovasc Res, 2007; Lavitrano et al, Reprod Fertil Dev, 2006;Lavitrano et al, PNAS, 2002)
    - Production of pre-clinical animal models for the study of ischemia - reperfusion injury (Andria et al, PLoS ONE, 2013; Lavitrano et al, FASEB J, 2004)
    - Production of multi-gene transgenic pigs for xenotransplantation studies (Cinti et al, PLoSONE, 2015; De Giorgi et al, Plasmid, 2015; De Giorgi et al, Nucleosides Nucleotides Nucleic Acids, 2014; Vargiolu et al, Transpl Proc, 2010; Webster et al, Mol Reprod Dev, 2005)
    - Vectors for transgenesis: a) use of non-viral episomal vectors to genetically modify animals (Manzini et al, PNAS,2006); b) use of adeno-associated vectors for retino-specific gene therapy in pre-clnical animal models (Mussolino et al, Gene Ther, 2011)
    - Production of TET-conditional transgenic mouse models for the study of neurodegenerative disorders (Giovannoni et al, Neuron Glia Biology, 2007; Canzoniere et al, J Neurosci, 2004

Internal and external collaborators

Selected pubblications

    - Romano G, Santi L, Bianco MR, Giuffrè MR, Pettinato M, Bugarin C, Garanzini C, Savarese L, Leoni S, Cerrito MG, Leone BE, Gaipa G, Grassilli E, Papa M, Lavitrano M, Giovannoni R. The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells. Oncotarget. 2016 Mar 3. doi: 10.18632/oncotarget.7895. PMID: 26956045
    - Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito MG, Masiero L, Ianzano L, Giordano F, Cicirelli V, Narloch R, D'Amato F, Noli B, Ferri GL, Leone BE, Stanta G, Bonin S, Helin K, Giovannoni R, Lavitrano M. A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation. Oncogene. 2016 Jan 25. doi: 10.1038/onc.2015.504. PMID: 26804170
    - Giovannoni R, Villanueva A. Circulating tumor cells and cholangiocarcinoma. Hepatology. 2016 Jan;63(1):23-5. doi: 10.1002/hep.28152. PMID: 26358526
    - De Giorgi M, Cinti A, Pelikant-Malecka I, Chisci E, Lavitrano M, Giovannoni R, Smolenski RT. Co-expression of functional human Heme Oxygenase 1, Ecto-5'-Nucleotidase and ecto-nucleoside triphosphate diphosphohydrolase-1 by "self-cleaving" 2A peptide system. Plasmid. 2015 May;79:22-9. doi: 10.1016/j.plasmid.2015.03.004. PMID: 25779031
    - Cinti A, De Giorgi M, Chisci E, Arena C, Galimberti G, Farina L, Bugarin C, Rivolta I, Gaipa G, Smolenski RT, Cerrito MG, Lavitrano M, Giovannoni R. Simultaneous Overexpression of Functional Human HO-1, E5NT and ENTPD1 Protects Murine Fibroblasts against TNF-α-Induced Injury In Vitro. PLoS One. 2015 Oct 29;10(10):e0141933. doi: 10.1371/journal.pone.0141933. PMID: 26513260

    last update: January 2017