Department and institution: School of Medicine and Surgery, Department of Health Sciences, University of Milano Bicocca
1) Toxic effects of 2,3,7,8 tetrachloro dibenzo-p-dioxin (TCDD) in humans,
2) Biochemical and molecular risk factors in cardiovascular diseases,
3) Development of advanced methods for the clinical diagnosis,
4) Molecular biochemistry of CDC2,
Keywords: TCDD, CVD, CDC2, Mass Spectrometry
Positions and Honors:
since 2006 Associate Professor of Clinical Biochemistry and Clinical Molecular Biology at the University of Milano Bicocca School of Medicine and Director of the University Department of Laboratory Medicine - Hospital of Desio - Milan.
1975 Graduation with full score and “magna cum laude” in Medicine at the University of Milan;
1979 PhD. with full score and “magna cum laude” in Laboratory Medicine;
1976 – 1990: biochemical monitoring plan of almost 20’000 people exposed to Dioxin at Seveso,
1986 – 1993: biochemical study in the Brianza centre of MONICA (MONItoring trends and determinants in Cardiovascular diseases) a multicenter WHO international epidemiological study
1992 – 1998: biochemical epidemiology for the GISSI prevenzione study
1987 – now: toxicity in Humans of TCDD (dioxin) in collaboration with Dr. Larry L. Needham e Dr. Donald G. Patterson, Centers for Disease Control (CDC), Atlanta (GA), (USA)
1995 – now: SWHS (Seveso Women Health Study) in collaboration with Professor Brenda Eskenazy, University of California at Berkeley, (USA).
In these projects biological banks and data banks have been created and still maintained.
Main research activity:
1976 – now: Study of toxic effects on human health by the environmental pollutant Dioxin. In particular the induction of biochemical modifications and endocrine disruption have been investigated. The effects of Dioxin on male reproductive system include an excess of female births and modification of semen quality depending on age at exposure to Dioxin have been reported;
1984 – now: Biochemical and molecular risk factors in chronic and degenerative diseases;
1990 – 2004: Study of the structure – function relationship in the CDC2 Kynase by mean of site directed mutagenesis;
2006 – now: Use of Mass Spectrometry in the Clinical Laboratory.
61 papers(impact factor 537,805)
Official H Index: 22