Paolo Brambilla - Associate Professor
Department and institution: Department of Health Sciences, School of Medicine and Surgery, University of Milano Bicocca
tel. +39 03 6238 3022
institutional profile page: UNIMIB
see also: PubMed, BOA
Keywords: TCDD, CVD, CDC2, Mass Spectrometry
1) Toxic effects of 2,3,7,8 tetrachloro dibenzo-p-dioxin (TCDD) in humans,
2) Biochemical and molecular risk factors in cardiovascular diseases,
3) Development of advanced methods for the clinical diagnosis,
4) Molecular biochemistry of CDC2,
Positions and Honors:
since 2006 Associate Professor of Clinical Biochemistry and Clinical Molecular Biology at the University of Milano Bicocca School of Medicine and Director of the University Department of Laboratory Medicine - Hospital of Desio - Milan.
1975 Graduation with full score and “magna cum laude” in Medicine at the University of Milan;
1979 PhD. with full score and “magna cum laude” in Laboratory Medicine;
1976 – 1990: biochemical monitoring plan of almost 20’000 people exposed to Dioxin at Seveso,
1986 – 1993: biochemical study in the Brianza centre of MONICA (MONItoring trends and determinants in Cardiovascular diseases) a multicenter WHO international epidemiological study
1992 – 1998: biochemical epidemiology for the GISSI prevenzione study
1987 – now: toxicity in Humans of TCDD (dioxin) in collaboration with Dr. Larry L. Needham e Dr. Donald G. Patterson, Centers for Disease Control (CDC), Atlanta (GA), (USA)
1995 – now: SWHS (Seveso Women Health Study) in collaboration with Professor Brenda Eskenazy, University of California at Berkeley, (USA).
In these projects biological banks and data banks have been created and still maintained.
Main research activity:
1976 – now: Study of toxic effects on human health by the environmental pollutant Dioxin. In particular the induction of biochemical modifications and endocrine disruption have been investigated. The effects of Dioxin on male reproductive system include an excess of female births and modification of semen quality depending on age at exposure to Dioxin have been reported;
1984 – now: Biochemical and molecular risk factors in chronic and degenerative diseases;
1990 – 2004: Study of the structure – function relationship in the CDC2 Kynase by mean of site directed mutagenesis;
2006 – now: Use of Mass Spectrometry in the Clinical Laboratory.
61 papers(impact factor 537,805)
Official H Index: 22
Selected Recent Publications
Ames, J., Warner, M., Brambilla, P., Mocarelli, P., Satariano, W., & Eskenazi, B. (2018).
Neurocognitive and physical functioning in the Seveso Women's Health Study.
ENVIRONMENTAL RESEARCH, 162, 55-62. MORE
Cristoni, S., Dusi, G., Brambilla, P., Albini, A., Conti, M., Brambilla, M., et al. (2017).
SANIST: optimization of a technology for compound identification based on the European Union directive with applications in forensic, pharmaceutical and food analyses.
JOURNAL OF MASS SPECTROMETRY, 52(1), 16-21. MORE
Waldeyer, C., Makarova, N., Zeller, T., Schnabel, R., Brunner, F., Jørgensen, T., et al. (2017).
Lipoprotein(a) and the risk of cardiovascular disease in the European population: results from the BiomarCaRE consortium.
EUROPEAN HEART JOURNAL. MORE
Intra, J., Sala, M., Falbo, R., Cappellini, F., & Brambilla, P. (2017).
Improvement in the detection of enteric protozoa from clinical stool samples using the automated urine sediment analyzer sediMAX® 2 compared to sediMAX® 1.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 36(1), 147-151. MORE
Coccè, V., Vitale, A., Colombo, S., Bonomi, A., Sisto, F., Ciusani, E., et al. (2016).
Human skin-derived fibroblasts used as a 'Trojan horse' for drug delivery.
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 41(4), 417-424. MORE