Mario Strazzabosco - Full Professor

Foto_Strazzabosco 150x150 Department and institution: School of Medicine and Surgery, University of Milano Bicocca
tel. +39 02 6448 8052
Curriculum Vitae
institutional profile page: UNIMIB
see also: PubMed, BOA

Keywords: Biliary Pathophysiology, Liver Cancer, Cirrhosis, Liver Transplantation, Regenerative Medicine

Research interests

    The Laboratory of Prof. Strazzabosco is deeply involved in the dissection of the molecular pathways leading to genetic and developmental cholangiopathies as well as tumor development. In particular the main research topics are i) the study of the role of TLR4-NF-kB axis in the regulation of the innate immune response in the biliary epithelium of Primary Sclerosing Cholangitis and Cystic Fibrosis, both cholangiopathies characterized by fibrosis and necro-inflammation; ii) the role of fibocystin in the onset of parainflammation and deposition of portal fibrosis in fibropolycystic liver diseases (Caroli’s disease and Congenital Hepatic Fibrosis) iii) the role of Notch signaling in liver regeneration and repair in non-alcoholic steatohepatitis; iv) the molecular mechanism of tumor progression and lymphatic invasion in Cholangiocarcinoma.

Current research projects

    Title: CFTR modulates innate immune response in the biliary epithelium. Role in the pathogenesis of cystic fibrosis-related liver disease
    Agency: NIH/NIDDK
    ID#: RO1DK096096
    Project Period: 04/01/2013-03/31/2018

    Title: Epithelial Angiogenic Signaling in Polycystic Disease of the Liver
    Agency: NIH/NIDDK
    ID# RO1 DK-079005-07
    Project Period: 07/01/2014-03/31/2019

    Title: Silvio O. Conte Digestive Disease Research Core Center
    Agency: NIH/NIDDK
    ID#: P30 DK-034989-31
    Project period: 09/01/14-8/31/19

    Title: CFTR-defective biliary cells from human Induced Pluripotent Stem Cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver diseases.
    Agency: FFC
    ID#: 24/2015
    Project period: 09/01/2015-8/31/2017

    Title: CFTR-deficiency causes a dysregulation in toll-like receptor-mediated innate immune responses: pathogenetic and therapeutic implications for cystic fibrosis-related liver disease
    Agency: TELETHON
    Project period: 10/01/2013-09/30/2016

    Title: Platelet derived growth factor-D stimulates the invasive properties of cholangiocarcinoma modulating tumor-stroma interactions
    Agency: University of Milan-Bicocca, Fondo di Ateneo Quota Competitiva
    P.I. Mario Strazzabosco M.D., Ph.D
    Project period: 12/01/2015-30/11/2017

Internal and external collaborators

Selected pubblications

    1: Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016;63:965-982. doi: 10.1002/hep.28382.
    2: Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology.
    2015;62:1828-1839. doi: 10.1002/hep.28138.
    3: Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology. 2015;62:1551-1562. doi: 10.1002/hep.28000.
    4: Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology. 2013;58:1713-1723. doi: 10.1002/hep.26554.
    5: Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. Gastroenterology. 2011;141:1498-1508, 1508.e1-5. doi: 10.1053/j.gastro.2011.06.052.

    last update: January 2018