Giovanni Cazzaniga - Assistant Professor
Department and institution: Genetics, Department of Health Sciences, School of Medicine and Surgery, University of Milano Bicocca and Centro Riccerca Matilde Tettamanti/Fondazione Tettamanti ONLUS, Monzagiovanni.cazzaniga@unimib.it
Curriculum Vitae
lab's website: Genetica molecolare delle leucemie pediatriche
other related links: www.fondazionetettamanti.it
see also: Google Scholar, ResearchGate, ORCID: 0000-0003-2955-4528
Publications (IRIS - Institutional Research Information System)
Keywords: pediatric hematology-oncology, acute lymphoblastic leukemia, genetic predisposition, personalized medicine
-
Abstract image
Cazzaniga Research interests >>>
Main topics of the group
Pediatric acute lymphoblastic leukemia: genetic predisposition, preleukemia and drug targeting.
Current research projects
1) Leukemia predisposition (familiarity, Syndromes), COST application; A.Selicorni (Como), T.Te Kronnie (PD), I-BFM (Syndromes, familiarity)
2) Pre-Leukemia in t(12;21); PRIN; Serafini/D’Amico; Gentner (HSR), P.Menendez (Barça)
3) Personalized Medicine; TRANSCAN, AIRC to GC, Appl. Roche; V. Bystry (Brno), De Bellis (CNR)
4) Biomarkers, function, drug response; T.Te Kronnie (PD), Storlazzi (Bari), R.Stam (Rot’dam), P.Menendez (Barça); AIRC to GC/AB
Selected pubblications
1. Bardini M, Woll PS, Corral L, Luc S, Wittmann L, Ma Z, Lo Nigro L, Basso G, Biondi A, Cazzaniga G,* Jacobsen SE*. Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement. Leukemia. 2014 May 6. doi: 10.1038/leu.2014.154. [Epub ahead of print] *(co-corresponding authors)
2. Cazzaniga V, Bugarin C, Bardini M, Giordan M, Te Kronnie G, Basso G, Biondi A, Fazio G, Cazzaniga G. LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients. Oncotarget. 2015;6:1569-81.
3. Cianci P, Fazio G, Casagranda S, Spinelli M, Rizzari C, Cazzaniga G, Selicorni A. Acute myeloid leukemia in Baraitser-Winter cerebrofrontofacial syndrome. Am J Med Genet A. 2017 Feb;173(2):546-549
4. Savino AM, Sarno J, Trentin L, Vieri M, Fazio G, Bardini M, Bugarin C, Fossati G, Davis K, Gaipa G, Izraeli S, Meyer LH, Nolan GP, Biondi A, Te Kronnie G, Palmi C, Cazzaniga G. The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL. Leukemia. 2017 Mar 23. doi: 10.1038/leu.2017.93. [Epub ahead of print]
5. Cazzaniga G, Bisanti L, Randi G, Deandrea S, Bungaro S, Pregliasco F, Perotti D, Spreafico F, Masera G, Valsecchi MG, Biondi A, Greaves M. Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster. Leukemia. 2017 Apr 27. doi: 10.1038/leu.2017.127. [Epub ahead of print]
last update: November 2020