Francesca Re - Associate Professor
Department and institution: Department of Health Sciences, School of Medicine and Surgery, University of Milano Bicocca
tel. +39 02 6448 8311
institutional profile page: UNIMIB
see also: PubMed
Publications (IRIS - Institutional Research Information System)
lab's website: CNLAB (Clinical Nanobiochemistry Laboratory)
Keywords: nanomedicine, nanoparticles, biochemistry, clinic
Research in Neuroscience, Nanotechnology and Nanomedicine in particular in the study of the interactions between lipids and proteins involved in neurodegenerative diseases through the use of nanoparticles, in particular nanoliposomes. Preparation and characterization of nanoparticles for therapy and diagnosis of Alzheimer's disease. Functionalization of nanoparticles for crossing the blood-brain barrier (in vitro and in vivo studies). Functionalization of nanoparticles to control the aggregation of amyloid proteins. Functionalization of nanoparticle for gene therapy of melanoma and for therapy of rheumatoid arthritis. Evaluation of biocompatibility of nanoparticles for biomedical use.
Main topics of the group
- design of biotech nanosized systems for brain
- design of bio-mimetic systems
- advanced in vitro cellular models of biological barriers
- gene therapy with nanodevices
Current research projects
- IMMUN-HUB 2019: immunotherapy against tumors
- FRRB Lombardia 2019 New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders (NEVERMIND)
- H2020 JPND 2016 Development of novel multicellular in vitro models of Alzheimer disease-like BBB
- PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE: targeting brain cholesterol transport in Alzheimer’s Disease
Re Francesca was born in a Busto Arsizio (VA) on 16/07/1981. Master of Science degree in Medical Biotechnology on 15/07/2005 at University of Milano-Bicocca. PhD in Neuroscience (04/12/2008) at Università of Milano-Bicocca. At Department of Experimental Medicine, University of Milano-Bicocca she performed her research activities on preparation and characterization of nanoparticles for Alzheimer’s disease therapy as project collaborator (from 12/2008 to 01/2009); she has won of research grant (from 02/2009 to 12/2009) and she was researcher at fixed time (from December 2009 to December 2012). She has conducted research abroad at Department of Biological Sciences, University of Warwick, Coventry CV4 7AL (UK) and at Neurogenetics laboratory, Academic Medical Center (AMC), University of Amsterdam, Amsterdam (NL). She is professor of Pathophysiology at Faculty of Biotechnology and Biosciences, degree in Biotechnology at the University of Milan-Bicocca, Professor of Nanomedicine to the Master of Science degree in Medical Biotechnology at University of Milan-Bicocca, professor of structure, function and metabolism of biological molecules to the Degree Course in Medicine and Surgery at University of Milan-Bicocca; contributor to tutoring-integrative educational, preparatory and recovery (School of Biochemistry) at Faculty of Medicine, Master of Science in Medicine at University of Milan-Bicocca. She holds of an international patent No. MI2008A001052 of 06.10.2008 entitled "Liposomes able to efficiently bind the peptide beta-amyloid" and of a U.S. patent No. 13/536, 851 of 28.06.2012 entitled "Liposomes active in vivo on neurodegenerative diseases (Alzheimer's disease in particular)." She has participated in more than 20 international conferences and more than half as invited speaker. She is reviewer of several papers on international journals. She is coordinator of a project entitled “Evaluation of the toxicity of nanoparticles designed for the therapy and diagnosis of neurodegenerative diseases” funded by Fondazione Banca del Monte di Lombardia (€ 20.000). She is in the Editorial Board of Nanobiomedicine Journal. She has won the competition “63rd Lindau Nobel Laureate Meeting in Chemistry” (2013).
see also: Publications (IRIS - Institutional Research Information System)
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB . J Nanobiotechnology. 2019 Nov 11;17(1):115. doi: 10.1186/s12951-019-0546-3
Beatrice Formicola, Roberta Dal Magro, Carlos V Montefusco-Pereira, Claus-Michael Lehr, Marcus Koch, Laura Russo, Gianvito Grasso, Marco A Deriu, Andrea Danani, Sandrine Bourdoulous, Francesca Re
The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro. Front Neurosci. 2019 May 16;13:419. doi: 10.3389/fnins.2019.00419. eCollection 2019.
Roberta Dal Magro, Sara Simonelli, Alysia Cox, Beatrice Formicola, Roberta Corti, Valeria Cassina, Luca Nardo, Francesco Mantegazza, Domenico Salerno, Gianvito Grasso, Marco Agostino Deriu, Andrea Danani, Laura Calabresi, Francesca Re
Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier. ACS Nano. 2018 Jul 24;12(7):7292-7300. doi: 10.1021/acsnano.8b03500.
Alysia Cox, Patrizia Andreozzi, Roberta Dal Magro, Fabio Fiordaliso, Alessandro Corbelli, Laura Talamini, Clizia Chinello, Francesca Raimondo, Fulvio Magni, Maria Tringali, Silke Krol, Paulo Jacob Silva, Francesco Stellacci, Massimo Masserini, Francesca Re
last update: June 2020