Department and institution: Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi” INGM.
Keywords: non-coding genome, epigenetics, 3D-structure, Polycomb, muscle skeletal differentiation.
1. Role of DNA repetitive elements in maintaining cell identity and coordinating transcriptional programs during cellular differentiation.
2. Epigenetic role of D4Z4 repeat in Facioscapulohumeral Dystrophy manifestation and progression.
3. Interplay between DNA repeats and Polycomb repressive complex in cancer transformation.
Date of Birth: February 11, 1980
Place of Birth: Lecco, Italy
Present affiliation and work address:
Istituto Nazionale Genetica Molecolare - INGM
Via Francesco Sforza 35
Telephone Number: +390200660302
Fax Number: +390200662346
Education and training
2006 PhD in Biotechnology Applied to Medical Sciences, University of Milan (Prof. Enrico Ginelli)
2003 Bachelor’s Degree in Medical Biotechnology, University of Milan (Prof. Anna Marozzi)
Research and Professional Experience
2013 – to date: Junior Program Leader of Genome Biology Unit, INGM, Milan.
2009-2013: Senior PostDoctoral Fellow in the lab of Epigenetics and Genome Reprogramming, Dr. Valerio Orlando, Fondazione Santa Lucia, Rome.
2006-08 PostDoctoral Fellow in the lab of Functional Genomics, Prof. Enrico Ginelli, University of Milan.
2003-2006 PhD student in the lab of Functional Genomics, Prof. Enrico Ginelli, University of Milan.
2010 – Postdoctoral fellowship from AFM Telethon French foundation (http://www.afm-telethon.com/) with a project entitled " Dissecting the role of repetitive DNA elements in Duchenne Muscular Dystrophy" (two years incl. renewal)
2008 – Nomination for Genomic Pioneers Award for outstanding contribution to the field of Genomics - Human Genome Meeting (HGM) Hyderabad 27-30 September
2008 – European Society of Human Genetics “Young Scientist” Award
2008 – Chiara D’Onofro “Young Investigator” Award (Most prestigious award in Cellular and Molecular Biology in Italy)
2008 – Research Assistant Fellowship (Assegno di Ricerca) from University of Milan (four years incl. renewal)
2008-Present – SIBBM (Italian Society of Biophysics and Molecular Biology) Fantom_5 2010-Present – Consortium Project, official collaborator (RIKEN OMICS CENTER, Yokohama, Japan)
2008- Present – Ad hoc Reviewer Stem Cells, FEBS letters, Human Genetics, PLoS ONE, BMC Genomics, BMC Medical Genomics, Frontiers in Cellular Neuroscience.
Giussani M, Cardone MF, Bodega B, Ginelli E, Meneveri R. (2012) Evolutionary history of linked D4Z4 and Beta satellite clusters at the FSHD locus (4q35). Genomics, 100(5):289-296.
Cabianca DS, Casa V, Bodega B, Xynos A, Ginelli E, Tanaka Y, Gabellini D. A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy. (2012) Cell, May 11;149(4):819-31.
Stojic L*, Jasencakova Z*, Prezioso C*, Stutzer A, Bodega B, Pasini D, Klingberg R, Mozzetta C, Margueron R, Puri PL, Schwarzer D, Helin K, Fischle W, Orlando V. (2011) Chromatin regulated interchange between PRC2-Ezh2 and PRC2-Ezh1 complexes controls Myogenin activation in skeletal muscle cells (2011) Epigenetics and Chromatin, 5;4:16. *Equal contribution
Bodega B*, Di Capua G, Grasser F, Cheli S, Brunelli S, Mora M, Meneveri R, Marozzi A, Muller S, Battaglioli E, Ginelli E. (2009) Remodelling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation. BMC Biology 7:41. *Corresponding author
Bodega B, Cardone MF, Muller S, Neusser M, Orzan F, Rossi E, Battaglioli E, Marozzi A, Riva P, Rocchi M, Meneveri R, Ginelli E. (2007) Evolutionary genomic remodelling of the human 4q subtelomere (4q35.2). BMC Evol Biology 14;7:39