Department and institution: School of Medicine and Surgery, Department of Health Sciences, University of Milano Bicocca
Keywords: Neuroprotection, Epilepsia, Neurohormones, GHS, Ghrelin
Current research interest are aimed at better defining the mechanisms involved in the endocrine and extraendocrine activities of the growth hormone secretagogues, such as their ability to modify food intake, cardiac function, acid gastric secretion and penile erection and anticonvulsant activity in epilepsy models. Other projects are aimed at the characterization in vitro of the mechanism of action of TLQP-21, a VGF derived neuropeptide involved in the control of energy metabolism.
Antonio Torsello, Ph.D., is an Associate Professor of Pharmacology at the Department of Heath Sciences, University of Milano-Bicocca. In the years 1988-89 has been working as Guest Researcher at the NICHD, NIH, Bethesda, USA and from 1990 to 1991 as Research Associate at the Department of Physiology, University of Manitoba, Winnipeg, Canada.
His main research interests are the characterization of receptor and second messenger systems mediating the effects of central and peripheral neurohormones and the mechanisms of control of anterior pituitary hormones. His research activity is documented by 82 publications on peer-reviewed international scientific journals, 11 monographs on international books and more than 70 communications in international and national congresses.
The most relevant results obtained deal with the characterization of adrenergic and cholinergic mechanisms of control of hypothalamic neurohormones involved in the somatotropic regulation. Other researches have been aimed at the study of the effects of the growth hormone secretagogues (GHS) on the somatotropic axis and also in the characterization of the extraendocrine effects of the. GHS on the cardiovascular system. More recently, we have investigated the anticonvulsant effects of some GHS in the pilocarpine model of epilepsia in the rat. The involvement of TLPQ-21, a VGF-derived peptide, in the regulation of energy metabolism is another research topic of our interest.