Department and institution: Biotechnology and Biosciences Department, University of Milano Bicocca
Keywords: Cell differentiation Gene regulation, Transcription factors, Erythropoiesis Globins genes
Mechanisms controlling cell specification and differentiation in hematopoiesis. Molecular control of erythropoiesis: -mechanisms of Hereditary Persistence of Fetal Hemoglobin: research on globin gene activity and function (mRNA translation, inherited structural and regulatory defects, transcriptional control). -transcriptional control of the expression of genes encoding erythroid transcription factors, in particular GATA 1 (and its transcriptional and post-transcriptional regulation) and Sox6. -study of the transcriptional regulation of the “stem cell” gene c-Kit -identification and functional analysis of genes differentially expressed during erythropoiesis -signal transduction mechanisms controlling cell commitment and differentiation in normal and pathological (leukemias, myelodysplastic syndromes) erythropoiesis In vitro biochemical assays, cell culture, transfections, and mouse models are employed in these studies.
from 2007 : Professore Associato in Genetica. 1997 : Ricercatore in Genetica 1992: Specialization in Biotechnology (PhD equivalent) 1988: Degree in Biological Sciences, Universita’ di Milano. RESEARCH ACTIVITY : 2000 to present: at Dipartimento di Biotecnologie e Bioscienze, Universita’ di Milano-Bicocca. 1989-2000: at Dipartimento di Genetica e di Biologia dei Microrganismi, Universita’ di Milano. 1992-1993: National Institute for Medical Research, London ( EMBO fellowship program)
1. Liberati C. et al. “Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon and gamma-globin gene promoters” J. Biol. Chem. 276:41700-41709 (2001).
2. Bosè F. et al. “Functional interaction of Cp2 with Gata-1 in the regulation of erythroid promoters”. Molecular and Cellular Biology 26:3942-54 (2006).
3. Cantù C et al. Sox6 enhances erythroid differentiation in human erythroid progenitors. Blood 117:3669-79. (2011).
4. Cantu' C. et al. “SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells. Nucleic Acids Res. 39:486-501 (2011).
5. Cantu' C et al. “Defective erythroid maturation in gelsolin mutant mice”. Haematologica. (2012).