Andrea Becchetti - Associate Professor
Department and institution: Biotechnology and Biosciences Department, University of Milano Bicocca
tel. +39 02 6448 3301
lab's website: Andrea Becchetti Research Group
institutional profile page: UNIMIB and Biotechnology and Biosciences Department
see also: PubMed, BOA
Keywords: Cerebral cortex; epilepsy; hypocretin; ion channels; synaptic function.
- Andrea Becchetti is currently studying the cholinergic and peptidergic regulation of local neuronal circuits in the mammalian prefrontal cortex. This modulates vigilance, cognition and the sleep-waking cycle, with pathological implications in different pathologies, such as sleep-related epilepsy and narcolepsy.
- He is also studying the regulatory interaction between voltage-gated potassium channels and integrin receptors, implicated in synaptic maturation and, outside the nervous system, in tumor growth and invasiveness.
Main topics of the group
- Cholinergic and peptidergic modulation of prefrontal circuits.
- Nicotinic receptors and K+ channels in neocortex development.
- Functional interplay between integrin-mediated cell adhesion and voltage-gated K+ channels.
Current research projects
- Acetylcholine and hypocretin in the cerebral cortex: functional aspects and implications in epilepsy and narcolepsy.
- Main grant: Telethon GGP12147
- Partners: see collaborators.
Internal and external collaborators
- Dr. Alida Amadeo, University of Milano Bicocca
- Prof. Annarosa Arcangeli, University of Florence.
- Prof. giulia Curia, University of Modena and Reggio Emilia.
- Dr. Anne Vassalli, University of Lausanne (Suisse).
Selected Recent Publications
The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells.
BRITISH JOURNAL OF CANCER, 118(2), 200-212. MORE
hERG Channels: From Antitargets to Novel Targets for Cancer Therapy.
CLINICAL CANCER RESEARCH, 23(1), 3-5. MORE
α4β2* nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex.
NEUROSCIENCE, 340, 48-61. MORE
The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.
SCIENCE SIGNALING, 10(473), 1-13. MORE