Andrea Becchetti - Associate Professor

Andrea Becchetti - Dimet 150x150 Department and institution: Biotechnology and Biosciences Department, University of Milano Bicocca
tel. +39 02 6448 3301
Curriculum Vitae
lab's website: Andrea Becchetti Research Group
institutional profile page: UNIMIB and Biotechnology and Biosciences Department
see also: PubMed, BOA

Keywords: Cerebral cortex; epilepsy; hypocretin; ion channels; synaptic function.

Research interests

    - Andrea Becchetti is currently studying the cholinergic and peptidergic regulation of local neuronal circuits in the mammalian prefrontal cortex. This modulates vigilance, cognition and the sleep-waking cycle, with pathological implications in different pathologies, such as sleep-related epilepsy and narcolepsy.
    - He is also studying the regulatory interaction between voltage-gated potassium channels and integrin receptors, implicated in synaptic maturation and, outside the nervous system, in tumor growth and invasiveness.

Main topics of the group

    - Cholinergic and peptidergic modulation of prefrontal circuits.
    - Nicotinic receptors and K+ channels in neocortex development.
    - Functional interplay between integrin-mediated cell adhesion and voltage-gated K+ channels.

Current research projects

    - Acetylcholine and hypocretin in the cerebral cortex: functional aspects and implications in epilepsy and narcolepsy.
    - Main grant: Telethon GGP12147
    - Partners: see collaborators.

Internal and external collaborators

Selected Recent Publications

  • Pillozzi, S., D'Amico, M., Bartoli, G., Gasparoli, L., Petroni, G., Crociani, O., et al. (2018).
    The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells.
    BRITISH JOURNAL OF CANCER, 118(2), 200-212.

  • Arcangeli, A., & Becchetti, A. (2017).
    hERG Channels: From Antitargets to Novel Targets for Cancer Therapy.

  • Aracri, P., Meneghini, S., Coatti, A., Amadeo, A., & Becchetti, A. (2017).
    α4β2* nicotinic receptors stimulate GABA release onto fast-spiking cells in layer V of mouse prefrontal (Fr2) cortex.
    NEUROSCIENCE, 340, 48-61.

  • Becchetti, A., Crescioli, S., Zanieri, F., Petroni, G., Mercatelli, R., Coppola, S., et al. (2017).
    The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.
    SCIENCE SIGNALING, 10(473), 1-13.

  • last update - May 2018

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