Andrea Becchetti - Associate Professor

Andrea Becchetti - Dimet 150x150 Department and institution: Biotechnology and Biosciences Department, University of Milano Bicocca
tel. +39 02 6448 3301
Curriculum Vitae
lab's website: Andrea Becchetti Research Group
institutional profile page: UNIMIB and Biotechnology and Biosciences Department
see also: PubMed, BOA

Keywords: Cerebral cortex; epilepsy; hypocretin; ion channels; synaptic function.

Research interests

    - Andrea Becchetti is currently studying the cholinergic and peptidergic regulation of local neuronal circuits in the mammalian prefrontal cortex. This modulates vigilance, cognition and the sleep-waking cycle, with pathological implications in different pathologies, such as sleep-related epilepsy and narcolepsy.
    - He is also studying the regulatory interaction between voltage-gated potassium channels and integrin receptors, implicated in synaptic maturation and, outside the nervous system, in tumor growth and invasiveness.

Main topics of the group

    - Cholinergic and peptidergic modulation of prefrontal circuits.
    - Nicotinic receptors and K+ channels in neocortex development.
    - Functional interplay between integrin-mediated cell adhesion and voltage-gated K+ channels.

Current research projects

    - Acetylcholine and hypocretin in the cerebral cortex: functional aspects and implications in epilepsy and narcolepsy.
    - Main grant: Telethon GGP12147
    - Partners: see collaborators.

Internal and external collaborators

Recent Publications
see also: PubMed, BOA

    - Mesoporous silica nanoparticles trigger mitophagy in endothelial cells and perturb neuronal network activity in a size- and time-dependent manner.
    Int J Nanomedicine. 2017 May 8;12:3547-3559. doi: 10.2147/IJN.S127663. eCollection 2017.
    Orlando A, Cazzaniga E, Tringali M, Gullo F, Becchetti A, Minniti S, Taraballi F, Tasciotti E, Re F.

    - The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.
    Sci Signal. 2017 Apr 4;10(473). pii: eaaf3236. doi: 10.1126/scisignal.aaf3236.
    Becchetti A1, Crescioli S2, Zanieri F2, Petroni G2, Mercatelli R3, Coppola S4, Gasparoli L2, D'Amico M5, Pillozzi S2, Crociani O2, Stefanini M, Fiore A, Carraresi L, Morello V, Manoli S, Brizzi MF, Ricci D, Rinaldi M, Masi A, Schmidt T, Quercioli F, Defilippi P, Arcangeli A.

    - hERG Channels: From Antitargets to Novel Targets for Cancer Therapy.
    Clin Cancer Res. 2017 Jan 1;23(1):3-5. doi: 10.1158/1078-0432.CCR-16-2322. Epub 2016 Nov 30.
    Arcangeli A, Becchetti A.

Selected pubblications

last update: November 2017

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