Alessio Zippo - Researcher

Department and institution:
tel. +39
see also: PubMed

Keywords: Wnt/β-catenin Signalling; Epigenetics; Embryonic Stem Cells; Cancer Stem Cell; reprogramming; Myc oncogene.

Research interests

    We are currently focusing our attention on the molecular mechanisms through which the transcription factor Myc influences global chromatin structure in ESC using biochemical, molecular and genetic approaches. In particular we are determining the contribution of Myc in integrating environmental signals with the core regulatory transcription network.
    On the same line, we are also investigating whether Myc plays a key role in determining the formation of Cancer Stem Cells (CSC) by favoring the establishment of a stem cell-like epigenetic signature. We are focusing on the dynamic epigenetic changes occurring at defined loci in primary mammary epithelial cells going through a Myc-induced reprogramming towards a primitive stem cell-like state.
    In the same cellular context, we are also investigating the molecular mechanisms through which the activation of the Wnt/β-catenin pathway promotes the establishment and the maintenance of the mammary CSC. In particular, we will focus in analyzing the downstream effects of β-catenin activation at the chromatin level including the expression signature and the epigenetic state of the CSC.

Ongoing Projects

    Role of Myc in determining the epigenetic state of Embryonic Stem cell
    Epigenetic mechanisms controlling the establishment of Cancer Stem Cells
    Wnt/ β-catenin signaling in stem cells

Recent Publications
see also: PubMed

Selected Publications

last update: January 2018

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