Mario Strazzabosco - Full Professor
Department and institution: School of Medicine and Surgery, University of Milano Bicocca
tel. +39 02 64488052
see also: PubMed, BOA
Keywords: Biliary Pathophysiology, Liver Cancer, Cirrhosis, Liver Transplantation, Regenerative Medicine
The Laboratory of Prof. Strazzabosco is deeply involved in the dissection of the molecular pathways leading to genetic and developmental cholangiopathies as well as tumor development. In particular the main research topics are i) the study of the role of TLR4-NF-kB axis in the regulation of the innate immune response in the biliary epithelium of Primary Sclerosing Cholangitis and Cystic Fibrosis, both cholangiopathies characterized by fibrosis and necro-inflammation; ii) the role of fibocystin in the onset of parainflammation and deposition of portal fibrosis in fibropolycystic liver diseases (Caroli’s disease and Congenital Hepatic Fibrosis) iii) the role of Notch signaling in liver regeneration and repair in non-alcoholic steatohepatitis; iv) the molecular mechanism of tumor progression and lymphatic invasion in Cholangiocarcinoma.
Current research projects
Title: CFTR modulates innate immune response in the biliary epithelium. Role in the pathogenesis of cystic fibrosis-related liver disease
Project Period: 04/01/2013-03/31/2018
Title: Epithelial Angiogenic Signaling in Polycystic Disease of the Liver
ID# RO1 DK-079005-07
Project Period: 07/01/2014-03/31/2019
Title: Silvio O. Conte Digestive Disease Research Core Center
ID#: P30 DK-034989-31
Project period: 09/01/14-8/31/19
Title: CFTR-defective biliary cells from human Induced Pluripotent Stem Cells (iPSC) as a model to study the role of innate immunity in cystic fibrosis liver diseases.
Project period: 09/01/2015-8/31/2017
Title: CFTR-deficiency causes a dysregulation in toll-like receptor-mediated innate immune responses: pathogenetic and therapeutic implications for cystic fibrosis-related liver disease
Project period: 10/01/2013-09/30/2016
Title: Platelet derived growth factor-D stimulates the invasive properties of cholangiocarcinoma modulating tumor-stroma interactions
Agency: University of Milan-Bicocca, Fondo di Ateneo Quota Competitiva
P.I. Mario Strazzabosco M.D., Ph.D
Project period: 12/01/2015-30/11/2017
Internal and external collaborators
- Prof. Fabris Luca, Department of Molecular Medicine, University of Padova, Padova, Italy
- Prof. Spirlì Carlo, Section of of Digestive Diseases, Yale University School of Medicine, New Haven (CT), USA.
- Dr. Fiorotto Romina, Section of of Digestive Diseases, Yale University School of Medicine, New Haven (CT), USA.
1: Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris L, Strazzabosco M. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis. Hepatology. 2016;63:965-982. doi: 10.1002/hep.28382.
2: Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M. Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. Hepatology.
2015;62:1828-1839. doi: 10.1002/hep.28138.
3: Scirpo R, Fiorotto R, Villani A, Amenduni M, Spirli C, Strazzabosco M. Stimulation of nuclear receptor peroxisome proliferator-activated receptor-γ limits NF-κB-dependent inflammation in mouse cystic fibrosis biliary epithelium. Hepatology. 2015;62:1551-1562. doi: 10.1002/hep.28000.
4: Spirli C, Locatelli L, Morell CM, Fiorotto R, Morton SD, Cadamuro M, Fabris L, Strazzabosco M. Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis. Hepatology. 2013;58:1713-1723. doi: 10.1002/hep.26554.
5: Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, Strazzabosco M. Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice. Gastroenterology. 2011;141:1498-1508, 1508.e1-5. doi: 10.1053/j.gastro.2011.06.052.
last update: March 2016