Project Title: Oncogene induced senescence in ETV6/RUN X1 Pre-leukemia: Role and Targeting.
Project Title: Studying normal and malignant human hematopoiesis using an in vivo model of human bone marrow niche
Project Title: Developing tools to study epigenomics in MLL-rearranged AML.
Project Title: "Mitochondrial diseases related to mtDNA in childhood: genotype-phenotype correlation and characterization of novel phenotypes"
Project Title: Risposta immunitaria alle infezioni da candida
Project Title: "Pharmacological modulation of SERCA-phospholamban interaction in the heart"
Project Title: Identification of the targets of the Sox2 trascription factor mediating its function in the maintenance of brain cancer stem cells.
Project Title: Studio in vitro ed in vivo della nicchia midollare ottenuta da pazienti con leucemia linfoblastica acuta di tipo B
Project Title: Unraveling the mechanisms sustaining the TEL/AML1 positive pre-leukemic cell.
Project Title: Predisposizione genetica alla Leucemia Linfoblastica Acuta pediatrica.
Project Title: Targeting AML with bispecific CAR-T cells redirected against leukemia cells and the malignant niche
Project Title: Analisi tissutali contestuali ad alta densità in infiammazione, riparo e trasformazione. Tissue-based high-dimensional landscaping in inflammation, repair and transformation.
Project Title: Dissection of immune disregulation in RAG deficiency and development of novel gene correction strategies.
Project Title: Single molecule techniques as innovative tool for nanomedicine drug design
Project Title: Iron as nutrient and potential toxic element in different pathological disorders.
Project Title: Increase safety and efficacy of cancer adoptive immunotherapy
Project Title: Sviluppo e caratterizzazione di un nuovo anticorpo bispecifico diretto contro il BCMA (CD269) per il trattamento del mieloma multiplo.
Project Title: Retinal ganglion cells and organoids from inherited optic neuropathies: light on pathogenesis to fight blindness.
Project Title: The Ascending Reticular Activating System in cortical excitability modulation: physiological features and implications in sleep-realted pathologies
Project Title: Characterization of the somatic and germline mutation landscape of Triple Negative Myeloproliferative Neoplasms
Project Title: Finding key players in leukemia-stroma crosstalk as targets for new treatments
Project Title: Phosphoethanolamine as a molecular breaker for hyperactive mitochondria in hematologic malignancies.
Project Title: "Non-receptor tyrosine kinase Arg in clear renal cell carcinoma"
Project Title: Characterization of bone disease in mucopolysaccharidoses and study of neonatal therapy approaches in a MPS I mouse model
Project Title: Preclinical models and therapeutic strategies fot Ventilatory Induced Dyaphragmatic Dysfunction
Project Title: Integrated Mass Spectometry proteomic-based approaches: new frontiers in clinical diagnostics
Project Title: Inhaled Nitric Oxide Gas Beyond Vasodilation.
Project Title: Finding key players in leukemia-stroma crosstalk as targets for new treatments in childhood B Cell Precursor Acute Lyphoblastic Leukemia (BCP-ALL)
Project Title: Study of chromatin accessibility in health and disease.
Project Title: Isolation and characterization of fetal cells for non-invasive prenatal diagnosis of genetic diseases
Project Title: Ruolo di ActivinA nella nicchia midollare nella Leucemia.
Project Title: Circulating tumor-derived T lymphocytes (CTDL) from patients' blood: role in the response to cancer immunotherapy and disease course.
Project Title: "A nanomedicine approach for theranostic of central nervous system (CNS) diseases"
Project Title: Cellular and Molecular characterization of the infiltrating polarized MPs during the onset of heterotopic ossification (HO) in a mouse model of Fibrodysplasia Ossificans…
Project Title: Implication of cell-based mechanosensing in setting and progression of vascular pathology
Project Title: Dissecting the genetic architecture of primary biliary cholangitis through the application of novel bioinformatics tools
Project Title: Analysis of the molecular and cellular mechanisms underlying the impaired angiogenic ability of mesenchymal stromal cells derived from Shwachman-Diamond syndrome patients.
Project Title: Mechanisms of immune regulation in Celiac Disease.
Project Title: "Exploring the potential of the hematopoietic stem cell niche using a novel in vivo model"
Project Title: Biological conditions related to frailty and their effect on adult renal stem cells.
Project Title: "Mass-spectrometry analysis in glomerulonephritis"
Project Title: Improving targeted gene editing in hematopoietic stem cells for clinical translation
Project Title: Role of the transcription factor COUP-TFII in early erythropoiesis.
Project Title: Analysis of Activin-A's role in the BCP-ALL nich.
Project Title: "Role of nuclear architecture in cell differentiation"
Project Title: Improving outcomes in a mouse model of cardiac arrest and cardiopulmonary resuscitation
Project Title: Ruolo della neuroinfiammazione nella disfunzione mitocondriale e metabolica in modelli animali ed in-vitro di Parkinson.
Project Title: "Gene correction of CD4oLG gene in Tcells and HSPC for the treatment of X-linked HIGM1"
Project Title: Engineered CAR T cells for efficient multi targeting of B-cell acute lymphoblastic leukemia: preventing immune evasion and post-CAR T relapses.
Project Title: Le Canalopatie tra le patologie legate al sistema nervoso
Project Title: Modeling target treatment of high-risk childhood acute lymphoblastic leukemia.
Project Title: Caratterizzazione degli effetti dei recettori delle citochine uneage-specifici sulle cellule dendritiche derivate da monociti umani.
Project Title: Lentiviral-mediated gene transfer of TCIRG1 to correct osteoclast function in autosomal recessive osteopetrosis.
Project Title: Radiotherapy and immunotherapy combination for brain tumour and the potential role of focus ultrasound as enhancer: discovering a cutting-edge treatment of the future.
Project Title: TBA
Project Title: Transcriptional and epigenetic regulation of immune cells mediated by transposable elements in human health and cancer.
Project Title: Combinatorial antigen targeting of B-cell neoplasms by engineered CART cells.
Project Title: Harnessing tumor microenvironment by genetic engineering
Project Title: Studio delle sottopopolazioni di cellule dendritiche umane in diverse condizioni infiammatorie mediante analisi trascrizionale su singola cellula.
Project Title: Suppression of pathogenic: T cell responses by type 1 regulatory T-cells in multiple sclerosis
Project Title: Targeting genetically defined high risk subgroups of childhood acute lymphoblastic leukemia. Sviluppo di terapie innovative contro bersagli molecolari in sottogruppi di Leucemia Acuta…
Project Title: Targeting of the altered interactions between hematopoietic stem cells and the bone marrow niche in beta-thalassemia.
Project Title: Define the role of CD6 in modulating T cell response.
Project Title: "Prevention of Renal Injury by Nitric Oxide in Prolonged Cardiopulmonary Bypass: A Double Blind Controlled Randomized Clinical Trial in Cardiac Surgical Patients with…
Project Title: Generation of human neuronal models of Dravet Syndrome
Project Title: Study of immunological escape mechanisms in myeloid leukemia.
Project Title: Dissecting the role of heterochromatic conformation in cancer
Project Title: Genomic Profiling of Myeloid Malignancies and development of Precision Medicine Strategies Cellular and Molecular Mechanisms
Project Title: Next Generation Sequencing of Myelofibrosis in patients undergoing Allogenic Stem Cell Transplantation: Role of mutations in High Molecular Risk (HMR) genes on clinical…