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| Name: Giuseppe Miserocchi |
| E-mail: giuseppe.miserocchi@unimib.it |
| Department: Experimental Medicine - UNIMIB |
| Research Area(s): Biomedical application of nanoparticles, Oxygen transport pathway, Lung edema, Cardiorespiratory disorders in neonatology |
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Research Projects Studies on biomedical application of nanoparticles (imaging , drug targeted delivery) to evaluate the biophysical, biological and molecular aspects of nanoparticles-cell/tissue interaction, and their biological fate and transport in biological compartments. We study in particular the impact on the alveolar membrane and evaluate as well the potential of the alveolar route for drug delivery through the transcytosis process. The techniques employed allow to investigate membrane electrophysiology and transports, biological fate/accumulation/metabolism, intracellular trafficking, molecular biology.
Pathophysiology of lung edema with special attention to the endothelial cells of the air-blood barrier as early sensors in the process of interstitial matrix damage/repair. These studies have a wide interest concerning the role of the lung as a gas exchanger in relation to the cardiac function and a potential application in cardio-respiratory disorders, in neonatology, critical care, cardiology and pneumology. Techniques adopted rely on gas diffusion measurements, hydraulic interstitial pressure measurements by micropipette (servo-null system), structure-function studies.
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