Physiology and pathophysiology of the “oxygen transport pathway”. The study of central (i.e. cardiovascular) and/or peripheral (i.e. muscular) factors responsible of the reduced exercise capacity in different populations (paediatric patients with blood disorders, diabetes and patients with chronic obstructive pulmonary disease) represents a new area of investigation to better understand the pathophysiology of the “oxygen transport pathway” in these populations. The identification of the areas of dysfunction and the evaluation of the working capacity will assist to better define rehabilitative programs addressed directly at these patients, to improve the efficiency of the oxygen transport pathway and to enhance the quality of life.
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