Understanding host-pathogen interactions for the diagnosis & control of Immunity The host/pathogen interaction is poorly understood because establishment of an infection in host by a microorganism is a dynamic event. The complex interaction between the host and the pathogen can now be explored in more detail using microarrays. In this project, we will evaluate the genetic interaction of host and pathogenic bacteria during colonization in an attempt to elucidate and interpret the mechanistic roles of gene regulation in pathogenesis. Our goal is to develop a comprehensive knowledge of host/pathogen interactions during colonization and to elucidate how these interactions are affected by different cells of the immune system. These studies will lead to new and/or improved diagnostic techniques, new therapeutics and vaccines, and improved health management strategies for human infectious diseases. |
